Pro-FHH Calculation

Pro-FHH is a validated formula that allow assessing if a genetic testing (by molecular biology) is required (or not) in order to make the diagnosis of a PTH-related hypercalcemia with a concomitant PTH value within the ‘normal’ range.

Variables

Fasting calcemia (mmol/L)

Fasting calcemia (mg/L)

mmol/L mg/L

Fasting PTH (pg/mL)

PTH upper limit of normal value (pg/mL)

Creatininemia (µmol/L)

Creatininemia (mg/L)

µmol/L mg/L

Creatininuria assessed in 24-h urine (mmol/L)

Creatininuria assessed in 24-h urine (mg/L)

mmol/L mg/L

Calciuria assessed in 24-h urine (mmol/L)

Calciuria assessed in 24-h urine (mg/L)

mmol/L mg/L

Fasting creatininuria (mmol/L)

Fasting creatininuria (mg/L)

mmol/L mg/L

Fasting calciuria (mmol/L)

Fasting calciuria (mg/L)

mmol/L mg/L

Bone remodeling marker

Bone remodeling marker upper limit of normal value

Results

PTH Ratio Pro-FHH has not been validated in patients with elevated PTH values

BRM ratio

24h-CCCR

Fasting-CCCR

24h-Pro-FHH

Fasting-Pro-FHH

The predictive positive value for your patient to have a Primary Hyperparathyroidism is of 100%

You should consider a genetic test in order to avoid a Familial Hypocalciuric Hypercalcemia

Results

The result for your patient is :

PTH Ratio Pro-FHH has not been validated in patients with elevated PTH values

BRM ratio

24h-CCCR

Fasting-CCCR

24h-Pro-FHH

Fasting-Pro-FHH

The predictive positive value for your patient to have a Primary Hyperparathyroidism is of 100%

You should consider a genetic test in order to avoid a Familial Hypocalciuric Hypercalcemia

Credits: From Bertocchio JP et al. Pro-FHH: A Risk Equation to Facilitate the Diagnosis of Parathyroid-Related Hypercalcemia
J Clin Endocrinol Metab. 2018 Jul 1;103(7):2534-2542. doi: 10.1210/jc.2017-02773 by permission of Oxford University Press, accessible here : https://academic.oup.com/jcem/article/103/7/2534/4990772